1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity connected with bortezomib, a proteasome inhibitor Utilized in the remedy of several myeloma. Its synthesis or review is very important for ensuring the purity and safety in the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor inside the synthesis of abiraterone acetate, a drug Employed in the remedy of prostate cancer by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-ten-1): A important compound in the synthesis of imatinib, a drug that targets unique sorts of cancer, together with Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound used in the synthesis of docetaxel, a chemotherapy medication that treats a variety of cancers like breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): They're intermediates inside the synthesis of gemcitabine, an anti-most cancers drug. Their review is vital for optimizing the creation process and 7-dihydro-4-oxo-1H-pyrrolo[2 guaranteeing higher purity.
Lapatinib Intermediate (CAS NO. 231278-84-5): Lapatinib is utilized to treat breast most cancers, and these intermediates are involved in its generation.
Fulvestrant Intermediates: Fulvestrant is an estrogen receptor antagonist Utilized in the therapy of breast most cancers. Numerous intermediates help in the synthesis of the drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-16-9): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in treating cancers including ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy 2-difluoro-D-erythro-pentofuranos-1-ulose-3 drug used in the cure of colorectal most cancers and small cell lung cancer.
3-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is involved in the synthesis of adamantane derivatives, that have various applications, which includes antiviral Houses.
Vildagliptin Intermediates: Utilized in the manufacture of vildagliptin, an oral drug for form two diabetic issues that inhibits the enzyme DPP-4 to manage blood sugar stages.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is linked to the synthesis of assorted gluconic acid derivatives, which happen to be Employed in food stuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate two: A precursor while in the synthesis of canagliflozin, a medication utilised to control sort 2 diabetic issues by inhibiting sodium-glucose co-transporter two (SGLT2).